![]() ![]() In many cases, the vacuoles have been shown to represent accumulations of various lipids or cholesterol.Ĭortical vacuolization can occur as a spontaneous, age-related change (especially in rats) secondary to stress from various causes and from administration of many exogenous drugs and toxins, especially those that interfere with normal steroidogenesis in the adrenal cortex and/or perturb the hypothalamic-pituitary-adrenal hormonal axis (including normal secretion and metabolism of adrenocorticotropic hormone ). ![]() The vacuoles can range from a single to a few large vacuoles to multiple smaller ones. Even large focal lesions generally cause little to no compression. Adrenal cortical vacuolization in rats and mice is characterized by the accumulation of usually clear vacuoles within cortical cells, mainly in the zona fasciculata, although the zonae reticularis and glomerulosa are also often affected. ![]()
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